ETV6/RUNX1 FUSION GENE ABROGATION DECREASES THE ONCOGENICITY OF TUMOUR CELLS IN A PRECLINICAL MODEL OF ACUTE LYMPHOBLASTIC LEUKAEMIA

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia.The implication of Dress Women’s the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Method

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IBTIDAIYAH MADRASAH (MI) AND INTEGRATED ISLAMIC PRIMARY SCHOOL (SDIT) REQUEST OF ISLAMIC EDUCATION AND INTEGRAL PARADIGM IN THE SISDIKNAS LAW NO. 20 OF 2003

The emergence and existence of the madrasa cannot be separated from the Islamic reform movement which was initiated by the efforts of a number of religious intellectuals who were later developed by Islamic organizations in Java, Sumatra and Kalimantan.Educational institutions currently have three models that have developed in Indonesia, namely scho

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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations]

Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a 4 Channel LOC focus on access, infrastructure, human resources, and intensive care unit (ICU) services.Methods A cross-sectional survey was conducted among healthcare workers employed in 87 hospitals having medical

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Sepsis Disrupts Mitochondrial Function and Diaphragm Morphology

BackgroundThe diaphragm is the primary muscle of inspiration, and its dysfunction is frequent during sepsis.However, the mechanisms associated with sepsis and diaphragm dysfunction are not well understood.In this study, we evaluated the morphophysiological changes of the mitochondrial diaphragm 5 days after THIN HAIR sepsis induction.MethodsMale C5

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